Depression and anxiety are among the most common diseases of modern society. Depression is very problematic for any person, and also affects family relationships. In this regard, timely treatment of a depressed state helps to avoid very serious and even tragic situations in a person's life.

On this page we list all the best antidepressants that are actively used by doctors and clinics to treat depressive disorders in patients.

The Best Antidepressants List


Zoloft | Active Ingredient: Sertraline

Zoloft (international nonproprietary name - sertraline hydrochloride) is an antidepressant whose mechanism of action is to suppress the reuptake of serotonin in neurons. This means that the amount of serotonin at the junction of neurons and the speed of transmission of nerve impulses increases, which has a calming effect, helps to reduce anxiety, panic and depression.

Zoloft (Sertraline) is a mild antidepressant, therefore it is recommended to include it in the course of treatment of various depressions, including against diseases of internal organs accompanied by low moods or attacks of panic attacks (sudden onset and also suddenly ending panic attacks).

Zoloft (Sertraline) is also effective in treating hidden and atypical depressions, which manifest themselves as signs of various diseases of the nervous system and internal organs (including chronic pains) and are removed during the treatment of depression. The course of treatment with zoloft successfully removes both depressive symptoms, anxiety, signs of internal organs and autonomic nervous system, normalizes sleep and eliminates pain syndrome.

Recently, Zoloft (Sertraline) has been actively used to treat patients with organic (visible tissue changes) neurological diseases, accompanied by depression. A good effect is zoloft in Parkinson's disease (neurological disease characterized by violation of voluntary movements) and Alzheimer's disease.

When social phobias (communication disorders) Zoloft (Sertraline) is increasingly a drug of choice.


Citalopram | Active Ingredient: citalopram

Citalopram is one of the SSRI antidepressants with the highest 5-HT selectivity. The minimal profile of side effects and the very low ability for negative interaction in patients with renal, hepatic and metabolic dysfunctions make Citalopram an exemplary drug in the treatment of depression. One extensive literature review examines the pharmacology, pharmacokinetics, therapeutic effects and tolerability of Citalopram (acting substance). This substance possesses high SSRI-selectivity and has very little chemical affinity with adrenergic, dopaminergic, histaminergic and muscarine-cholinergic receptors. Citalopram is a highly lipophilic substance, which is very quickly and almost completely resorbed. Its pharmacokinetics are linear; The metabolism is carried out by the liver. The content in the blood plasma after a single dose is noted for almost 35 hours, which allows it to be used once a day. Unlike other SSRIs, the likelihood of drug interaction through CYP450 activation is extremely low. Numerous controlled clinical trials have shown high antidepressant efficacy of citalopram. A comparative study has shown that it is also effective, as tricyclic and other SSRI antidepressants.


Lexapro | Active Ingredient: Escitalopram

Lexapro (Escitalopram) belongs to the selective serotonin backbone blocker (SSRI). This drug is used in the treatment of major depressive disorder in children and adults, generalized anxiety disorder, obsessive - compulsive disorder, posttraumatic stress disorder, cataplexy and psychoses that developed against the background of dementia. Both citalopram and escitalopram consist of the enantiomers of S and R. These drugs increase serotonin levels for several hours, but the effect of escitalopram as an antidepressant develops within a few weeks. It should be noted that in some patients, low-dose therapy of escitalopram may be more effective than monotherapy of this drug in high doses.

For the safety of escitalopram therapy, it is recommended to periodically perform ECG (prolongation of the QTs segment). Especially in patients with familial complication of prolongation of QTs, with a predilection for cardiac arrhythmia, after acute myocardial infarction, with signs of heart failure. Of the side effects of Lexapro (Escitalopram) is nausea, sleep disturbance, weakness, doubt, hyperhidrosis, decreased libido, ejaculation delay and anorgasmia. Of the dangerous complications of escitalopram therapy, in addition to prolongation of QT, serotonin syndrome, progression of the closed-angle glaucoma, lowering the convulsive threshold (rarely), activation of manic syndrome and suicidal ideation, especially during several months of therapy. Very rarely observed hyponatremia and bleeding. The drug does not affect the body weight. If there are side effects, the drug should be reduced and its dose should be slowed, it is also necessary to remember the possibility of developing a withdrawal syndrome after stopping the use of Lexapro (Escitalopram).


Effexor XR | Active Ingredient: Venlafaxine

There are many ways to treat depression. Medications and psychotherapy are effective for most people. Your doctor or psychiatrist can prescribe medications to relieve the symptoms of depression. However, many people with depression also find relief in psychotherapy. In severe cases of depression, hospitalization or participation in outpatient programs may be necessary until symptoms of depression occur. Medications Various antidepressants are available to treat depression. Discuss possible side effects with your doctor. Effexor XR (Venlafaxine) is one of the effective medicines for treating depression. It refers to selective serotonin-norepinephrine reuptake inhibitors (SNRIs).


Wellbutrin SR | Active Ingredient: Bupropion

Wellbutrin SR (Bupropion) is an inhibitor of the reuptake of dopamine and norepinephrine + an antagonist of some nicotinic acetylcholine receptors. Wellbutrin SR (Bupropion) on the mechanism of action in some messaging is unique from all that is on the pharmaceutical market. Well goes in a complex with SSRIs in the treatment of resistant depressions, or for example if it is necessary to correct the SSRIs (starting from sexual and ending with ssri-induced apathy syndrome). Wellbutrin SR significantly reduces the threshold of convulsive activity (but this is only in vykovki doses is relevant). Wellbutrin SR (Bupropion) is one of the most beneficial antidepressant, when used within the BAP (very low risk of phase infertility, even lower than in SSRIs). But it is senseless to treat anxious disorders (at least in monotherapy), it is simply ineffective here.


Amitriptyline | Active Ingredient: amitriptyline

Amitriptyline is an antidepressant from a group of nonselective inhibitors of neuromediator capture. By chemical structure refers to tricyclic compounds. It is used in the treatment of many types of depressions and their somatic manifestations.

What is Amitriptyline for? The drug has antihistamine and holinoliticheskim action, which allows it to be used in spastic states of smooth muscles. The effect of the antidepressant Amitriptyline is that the drug prevents the reverse capture of synaptic clefts of such neurotransmitters as serotonin, dopamine, noradrenaline. This tricyclic compound promotes the accumulation of neurotransmitter mediators, prolonging and enhancing their action, which removes the symptoms of depression.

List of pathologies, from which Amitriptyline helps:

1. Depression of various origins, including with an anxious and apathetic component, as well as physical manifestations of mental disorders.

2. Food disorders, as a manifestation of depression: bulimia (wolfish famine), anorexia.

3. Preventing migraine attacks.

4. Bedwetting in children and a hyperactive bladder in adults.

5. Neuralgias and chronic pain syndrome in fibromyalgia, irritable bowel syndrome, oncological diseases, etc.

6. Various phobias.

7. Post-stroke state, especially in the elderly.

8. Abstinence syndrome, i.e. Abstention from alcohol and drugs. 9. Psychoses in schizophrenia.

Celexa | Active Ingredient: Citalopram

Not only does the diagnosis take time, but the selection of the most effective method of treatment is a long and delicate process. About 30% of patients taking antidepressants are not cured of depression. This may be related to the characteristics of the psychological or biological structure, or due to the inability to continue taking medication because of strong side effects. The very first method of treatment that a doctor will prescribe is taking antidepressants in combination with psychotherapy. If the prescribed antidepressant does not give the expected result, the doctor will prescribe another antidepressant of the same class - but with other side effects - or, in addition, an antidepressant of another class. You can also try changing the dose or taking two different antidepressants simultaneously. Selective serotonin reuptake inhibitors were released in the mid-1980s. To date, they are the most requested in the treatment of depression.

When using antidepressants of this class, you do not need to adhere to a special diet. They are safe even for patients with cardiovascular diseases, including cardiac arrhythmia and blood pressure changes. One of the effective drugs of this type is Celexa (Citalopram).


Elavil | Active Ingredient: Amitriptyline

Elavil (Amitriptyline) is used mainly with endogenous depression, but it is also used in the treatment of depression of any other etiology. Especially, Elavil (Amitriptyline) is effective in anxiety-depressive states; Reduces anxiety, psychomotor agitation (agitation), internal tension and fear, insomnia and actually depressive manifestations. Elavil (Amitriptyline) is also used for the treatment of phobic disorders, children's enuresis (except for children with hypotonic urinary bladder), psychogenic anorexia, bulimic neurosis, chronic pain syndrome neurogenic harater, and for the prevention of migraine. Usually amitriptyline does not cause exacerbation of delusions, hallucinations and other productive symptoms, which is possible with the use of antidepressants with a predominant stimulating effect (imipramine, etc.).

Cymbalta | Active Ingredient: Duloxetine

Cymbalta (duloxetine) - an antidepressant, is an inhibitor of reuptake of serotonin and norepinephrine, while it has a weak inhibitory effect on dopamine reuptake. Thus, the principle of his work is based on the increase of noradrenergic and serotonergic neurotransmission in the central nervous system. This is a modern drug whose dual mechanism of action has proven effective in treating depressions of varying severity. In addition to its high effectiveness, this antidepressant can boast a considerable speed of action. A distinct antidepressant effect is observed already in the first week of duloxetine. In addition, the drug is characterized by persistence and uniformity of action, which allows to observe continuous improvements throughout the treatment period. In addition, the Cymbalta (duloxetine) has a strong analgesic effect, occurring already during the first two weeks of taking the drug. The study of the effectiveness of duloxetine in the fight against chronic migraine proves that the drug can successfully cope with pain and increases the pain threshold. Of the 46 patients with chronic migraine, serious improvements have occurred in more than half. At the end of the three-month course of treatment, the average number of days without a headache (within one month) increased by approximately 60%, and the frequency of migraine attacks decreased by 40%.

Paxil | Active Ingredient: Paroxetine

How does Paxil (Paroxetine) act on a person suffering from depression or panic attacks? Paxil (Paroxetine) is able to selectively (that is, selectively) block the seizure of serotonin, and the result of this action is an antidepressant or anti-anxiety effect. That is why this drug is used only in this area. Paxil (Paroxetine) is a lifeline for people who are in a depressed state, and who are suicidal thoughts. As practice shows, this drug will cope, even if other medications that were previously taken by the patient were powerless. By the way, it is recommended to take it for the prevention of recurrence of depression. Why do many appoint Paxil (Paroxetine)? Because this is the drug that will not affect how sleeping pills on a person, while it does not impair the quality of sleep, that is, no additional means will not have to be applied to get rid of such consequences. Although if the patient has had trouble sleeping, the attending physician can decide whether to take such drugs in the complex.