Zoloft (Sertraline) 25/50/100mg for Anxiety

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Zoloft (sertralin) in psychiatry and general medical practice: the data of recent years

Zoloft (sertraline hydrochloride) belongs to the class of selective serotonin reuptake inhibitors and is well known to domestic psychiatrists as a highly effective antidepressant of a wide spectrum of action. The basis of the profile of psychotropic activity of the drug is a distinct timoanaleptic effect with a weak stimulating component.

In recent years a number of new data appeared in the specialized literature, shedding additional light on indications for the use of zoloft in various types of mental pathology, as well as in a number of psychosomatic disorders.

Depression. Zoloft for anxiety

Chronic depression

Zoloft for anxiety is one of the main antidepressants used in depressive states with a tendency to chronic. To achieve an obvious effect in these cases, it takes 3-4 weeks, and sometimes more. Usually the effect increases with the continuation of therapy. Nevertheless, in recent years, new data have appeared that confirm the high effectiveness of zoloft in the treatment of chronic depression. A long-term study (76 weeks) was performed by a group of American scientists who studied in a double-blind manner in 77 patients who received zoloft compared to the placebo group (n = 66). After a 3-month treatment of the acute phase of depression, patients received drugs for another 4-month period. The main purpose of the study was the possibility of preventing a new episode of depression. Patients were studied at 12 medical research centers in the United States. The results of the work confirmed the high effectiveness of sertraline as a preventive tool for preventing the exacerbation of depression. Depressive symptoms appeared against the background of sertraline treatment in only 20 (26%) of 77 patients versus 42 (50%) of the 84 patients who received the placebo. The authors conclude that sertraline is highly effective in the treatment of chronic depression.

Postpartum depression

This indication is also officially unregistered by the FDA, but researchers are willing to resort to Zoloft for anxiety in the treatment of this type of mental pathology. Thus, Epperson and co-authors presented the results of a study of the treatment of sertraline in women who had depression in terms of DCM-IV criteria in the postpartum period. The study was placebo-controlled, performed by a double-blind method for 6 weeks. Out of 13 women, six have completed the full course; 4 of 6 who completed the study were evaluated by the responders, 3 of whom received sertraline.

The authors come to the conclusion about the effectiveness of zoloft in the treatment of postpartum depressions.

In an open prospective study, Stowe and co-authors studied the effect of sertraline on postpartum depression in 26 patients. HAM-D status assessments occurred every 2 weeks, the zoloft dose was standard (25-50-100-200 mg / day). 21 women underwent the entire 8-week course of therapy, and in all cases there was an improvement from the second week of treatment. In 14 patients after the course was completed, complete remission was recorded. Sertraline was well tolerated, the side effects were insignificant and completely reduced by dose adjustment. Breastfeeding during the treatment was continued by 6 women, which did not affect the children in any way. The authors draw conclusions about the high efficacy and good tolerability of Zoloft for anxiety in postpartum depression, stating that after an open study, more in-depth approaches are needed.

Panic disorders

Despite the slight sedative effect, zoloft has a positive effect on patients with anxiety and panic disorders. At the same time, anxiety reduction occurs faster than on prozac therapy and some other antidepressants. Rapaport and co-authors studied the efficacy of sertraline in the treatment of panic disorders in an 80-week, multicentre study. During 52 weeks, 398 patients received sertraline, starting at 25 mg / day. Gradually, the dose was increased to 200 mg / day, depending on the tolerability and clinical response of patients. Respondents in the 2 nd phase of the study were divided into 2 groups (sertraline - 92 patients and placebo - 89 patients).

Approximately 70% in the zoloft group and 50% in the placebo group completed the study. Sertraline statistically significantly exceeded placebo for treatment effectiveness (p = 0.04) and prevention of new episodes of panic attack (p = 0.005). Zoloft for anxiety was well tolerated by patients, and this tolerance increased with the duration of treatment. Among the side effects in the sertraline group, headaches prevailed, in the group receiving the placebo, headaches, insomnia. Laboratory parameters in both groups did not differ significantly. The authors concluded that sertraline is an effective and safe remedy for the treatment of panic disorders.

Alcoholism and drug addiction

In an open 12-week study, Brady and co-authors evaluated the efficacy of sertraline (110 mg / day) in the treatment of PTSD complicated by alcoholism in 9 patients. It has been proven that taking zoloft reduces alcohol consumption (P≤0,0005) and increases the number of days free from alcohol (p≤0,001), after treatment with sertraline. George and co-authors presented preliminary results of an open pilot phase of a long two-stage study that assesses the effect of sertraline on the level of alcohol consumption. For 6 months in patients who received Zoloft for anxiety at a dose of 2.75 mg / kg / day, the frequency of alcohol consumption, the severity of alcohol dependence, the craving for alcohol were regularly assessed.

After the end of treatment, patients who underwent a course of therapy, found a significant decrease in alcohol consumption, the severity of alcohol manifestations.
It was noted that in 61% of cases the craving for alcoholic beverages decreased until the alcohol was completely abandoned. The authors draw preliminary conclusions that the treatment with sertraline seriously affects the dependence on alcohol. Eggerth and co-authors studied the effects of sertraline on the psychosocial problems of individuals with alcoholism in the same group of patients. After 6 months of treatment, the indices decreased by an average of 77.5 points. The greatest improvement was achieved in the first 2 months of therapy. Researchers conclude that treatment with zoloft does not only lead to a decrease in alcohol consumption, but also contributes to significant positive shifts in the psychosocial sphere of patients.

The work of recent years has greatly enriched the clinical experience of psychiatrists in working with sertraline. The variety of zoloft's action and the safety of its application expand the capabilities of clinicians in combating various types of mental pathology. Sertraline has been actively and successfully used in different age groups, somatic pathology is not an obstacle in the treatment of mental disorders by Zoloft for anxiety. And finally, sertraline remains a highly effective tool for treating various types of depression, and the steepness of these appointments is constantly expanding.

And finally, a review from one of the patients treated with Zoloft for anxiety

Anna S., 35 years old:

Hello to all healthy people and those who are moping. I read reviews about the drug Zoloft for anxiety and decided to share my story.

For several years of intensive work, during which my vacation was postponed, then moved back for an indefinite amount of time, I, of course, accumulated a huge bag of fatigue. And now, add an irregular working day, constant stress and problems in your personal life - everyone can. It was a long time ago, but I decided to go to a psychotherapist. He listened attentively to my complaints about the eternal nervous breakdowns, to which were also added panic attacks for no apparent reason, and prescribed me a prescription for antidepressants. I know, I know that some people go to the brainwatch only for fashion, but I did not recognize such "walks". And if I had not been a fan of any kind of psychological reading, I would not even have been thrust into it, that's for sure. A drop of optimism, left in me, said "we'll manage ourselves, we'll do without pills." The recipe I kept a few more years, and then in one of the general cleaning I threw it to the dogs. I'm strong, I told myself.

And here relatively recently - and to be more precise, in the winter - my exhausted emotional state could not stand it - it called for "help" physical condition. Every morning I hated the whole world, because I did not get enough sleep. I did not want to get out of bed until the last and right up to tears! I was irritated by absolutely everything. It was started and exploded with a half-turn. At first I wrote off everything on - again - nervous work, but my colleagues and relatives began to notice that something was amiss with me. When, in addition to unbalance, they began to surprise me from the panic attacks that rose from the dead, and completely finished off insomnia, considering that I was terribly sleepy, but could not, I sounded the alarm.

It seems to have been a few days before the moment when I flew a bullet to a friend of a neurologist, but the symptoms increased. All I will not list, but the stirring somewhere in the eye, disgusting state of health, etc. etc. The main thing that scared me to hell - catastrophic memory problems. Disgusting horrors, which I do not wish the enemy either. To read about this, perhaps, nothing special, but to feel all this bunch is not at all fun.

The diagnosis is depression. The recipe is atarax and Zoloft for anxiety. I took my leave, so, with a paper at a gallop in the pharmacy.

I attach a description (it does not fit, so it's interesting to anyone - the Internet to help) the medications prescribed to me.

Atarax I drank three hours before sleeping first on a quarter, then on a half, then kiss.

Zoloft in the morning in half, then in the whole.

As for the side effect of Zoloft for anxiety, this is a quiet horror. But, you know, I did not have a choice. I urgently needed to correct my condition, because I suffered from it, and my relatives. The first days of reception excited me, but I could not explain what it was. No nausea, no vomiting, no dizziness, etc. I was worried a little, but my behavior was extremely calm. I watched every emotion and as if watching, I looked at myself. From the "supernatural" - sweating. And that's it!

We sum up (perhaps, premature, but still) the results:

The medication was started on January 22, 2016, and finished on March 24, 2016.


I get enough sleep;
I feel vigorous;
I do not react to provocations;
Memory problems stopped;
Everything became brighter, more interesting, or something - somehow transformed;
Decreased appetite, weight loss (but here everything also coincided with the fact that until the new year I began to eat right);
Increased concentration of attention.

Honestly, now I live and do not grieve. I felt the full effect of taking medications about a month later. I really enjoy life, and what's important - every pleasant little thing. With the help of Zoloft for anxiety I returned myself.

I spent a lot of time already during the reception of Zoloft searching for information on the Internet. I thoroughly studied all the reviews here. At first I was frightened that the overwhelming majority wrote about suicidal tendencies and, to put it mildly, bad finals. Here I have two options: either this drug is not suitable for you, or the doctor who got you, not an expert in your case, and appointed you drugs that do not match your condition. Simply put, the diagnosis is incorrect.

Atarax I drank a month, and Zoloft I still drink. I plan a gradual cancellation by the summer, for the reception of alcohol shines (leave, all affairs), and Zoloft and alcohol are simply incompatible. By the way, from the beginning of taking the drug, I did not use a drop of alcohol. Is that one glass of champagne for a good reason - the birthday of my beloved dad.
I sincerely hope that my feedback helped someone.

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